Bio MEMS Research

My Research

Research involves constant investigating and redesigning of the scientific questions posed. The strength of my research lies in the experimental and statistical approaches I utilize in understanding various phenomena and then engineer them to achieve feasible solutions for the society. Learn more about my ongoing research projects below.

Plasmonic Drug Delivery Platform

Modern science traces the origin of various diseases to cellular and molecular level. Currently such studies use bulk ensembles of cells to obtain average data. However, keen studies on cellular platform show wide cell to cell heterogeneity. Individual cells could show huge deviation from the characteristics of the bulk ensembles. The loss of this low frequency data could not detect rare diseases or the diseases in their primeval stage. Microfluidics or Bio Micro Electro Mechanical systems (Bio – MEMS) integrated with micro-total analysis system (μ-TAS) system can provide a unique platform for single cell therapy and analysis. In the current work we demonstrate a microfabrication device based therapeutic platform for single cell intracellular drug delivery using pulsed laser interaction

Cell Patterning Technology

cell alignment can find applications in tissue engineering for development of regenerative medicine. Besides, this can help control the random positioning of cells on the substrate to provide better individual cell observability and trackability. This can be useful in studying cell lineage, cell signalling. In the current work we are proposing development of two dimensional patterned substrate for alignment of cells by providing different chemical stimulus specific to cells. Micro contact printing technique for substrate patterning is employed. Cells are seeded on pre patterned substrates. Based on the cell affinity to particular chemical stimulus, they get aligned on the substrate. Soft Lithography technique is employed for fabricating micro patterns on the substrate.